DBI2 publications

Heterogeneous encoding of temporal stimuli in the cerebellar cortex

Type Journal
Year 2023
Author Chris. De Zeeuw, Devika Narain
Link to publication Link to publication
DOI 10.1038/s41467-023-43139-9

Local feedforward and recurrent connectivity are rife in the frontal areas of the cerebral cortex, which gives rise to rich heterogeneous dynamics observed in such areas. Recently, similar local connectivity motifs have been discovered among Purkinje and molecular layer interneurons of the cerebellar cortex, however, task-related activity in these neurons has often been associated with relatively simple facilitation and suppression dynamics. Here, we show that the rodent cerebellar cortex supports heterogeneity in task-related neuronal activity at a scale similar to the cerebral cortex. We provide a computational model that inculcates recent anatomical insights into local microcircuit motifs to show the putative basis for such heterogeneity. We also use cell-type specific chronic viral lesions to establish the involvement of cerebellar lobules in associative learning behaviors. Functional heterogeneity in neuronal profiles may not merely be the remit of the associative cerebral cortex, similar principles may be at play in subcortical areas, even those with seemingly crystalline and homogenous cytoarchitectures like the cerebellum.

Chris. De Zeeuw, Devika Narain
Heterogeneous encoding of temporal stimuli, heterogeneity in task-related neuronal activity, Purkinje cell

Want to join DBI²?

Browse the vacancies page

Contact details

Radboud University
DBI2 Office
Heyendaalseweg 135
6525 AJ Nijmegen


twitter   displaying 19 gallery images for linkedin logo png 25