Scientific Publications

DBI2 publications

Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity

Type Journal
Year 2022
Author Chris de Zeeuw
Link to publication Link
DOI https://doi.org/10.1038/s42003-022-04283-y

Cerebellar learning is expressed as upbound or downbound changes in simple spike activity of Purkinje cell subpopulations, but the underlying mechanism remains enigmatic. By visualizing murine Purkinje cells with different molecular identities, we demonstrate that the potential for induction of long-term depression is prominent in downbound and minimal in the upbound subpopulation. These differential propensities depend on the expression profile, but not on the synaptic inputs, of the individual Purkinje cell involved, highlighting the functional relevance of intrinsic properties for memory formation.

 

Chris de Zeeuw
https://doi.org/10.1038/s42003-022-04283-y
Purkinje cells, Molecular identity, Postsynaptic plasticity, Long-term depression, Cerebellar learning

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